A new compound, kushenol Z (KZ), and 14 known flavonoids were isolated from SF. Compounds in Sophora flavescens possessing medicinal properties include oxymatrine, matrine and sophoridine. A decoction of root of sophora flavescens is applied on affected part to treat eczema, pruritus, scabies and colpitis. The Ben Cao Medical Book (also known as Compendium of Materia Medica or Ben Cao Gang Mu; Chinese: 本草纲目) is the most famous and comprehensive medical book ever written in the history of traditional Chinese medicine (TCM). Pills made with dried root of sophora flavescens and honey is taken with mint soup to treat high-grade fevers. On the basis of his predecessors’ achievements in the pharmacological studies, Li contributed further by supplementing and rectifying many past mistakes and misconception in relate to nature of many medicinal substances and causes of various illnesses. Sophora flavescens functions by influencing the heart, liver, stomach, large intestine and bladder. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes. Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. All Rights Reserved. ← Dictamnus Albus Root As Medicine – Ben Cao Medical Book, Cimicifuga Rhizoma As Medicine – Ben Cao Medical Book →, 5 Health Benefits of Soju - Ben Cao Medical Book, Health Benefits of Rubus Chingii - Ben Cao Medical Book, 4 Amazing Health Benefits of Pistachios - Ben Cao Medical Book, 4 Health Benefits of Cuscuta Chinensis - Ben Cao Medical Book, Health Benefits of Dioscorea Bulbifera - Ben Cao Medical Book, 5 Amazing Uses And Health Benefits of Lotus Leaves - Ben Cao Medical Book, Barn Swallows’ Mud Nest As Medicine – Ben Cao Medical Book, Bees’ Nest As Medicine – Ben Cao Medical Book, Dung Balls As Medicine – Ben Cao Medical Book. “Dogel ebs” was known as Sophora flavescens Ait., a classical traditional Chinese Mongolian herbal medicine, which had the effects on damp‐heat dysentery, scrofula, and syndrome of accumulated dampness toxicity. Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor. If you continue to use this site we will assume that you are happy with it. PXR- and CAR-mediated herbal effect on human diseases. Ku shen (the root) or kushenin (a flavonoid compound) is a typical traditional chinese medicine that is found in this plant. Concomitant oral administration of Sophora extract (0.158 g/kg or 0.63 g/kg, p.o.) 4. Some features of the site may not work correctly. It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein. Your email address will not be published. In traditional Chinese medicine (TCM), Sophora flavescens has been used extensively, mainly in combination with other medicinal plants in prescriptions to treat fever, dysentery, hematochezia, jaundice, oliguria, vulvar swelling, asthma, eczema, inflammatory disorders, ulcers and diseases associated with skin burns. Dispensary Register/Log In; Language: English. We use cookies to ensure that we give you the best experience on our website. The data are presented as means (n 3 at each concentration). The flavonoids of Sophora flavescens exerts anti‐inflammatory activity via promoting autophagy of ... Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong, China . St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17), together with 15 known alkaloids, were isolated from S. flavescens. This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. 100 A.D.). Sophora flavescens (Fabaceae), also known as Kushen (Chinese: 苦参), has been an important species in Chinese medicine since the Qin and Han dynasties. English; Chinese; CONTACT US: +44 (0) 1245 350822. Compiled and written by Li Shi-zhen (1518~1593), a medical expert of the Ming Dynasty (1368-1644) over 27 years. We use cookies and similar tools to enhance your shopping experience, to provide our services, understand how customers use … Your email address will not be published. It has a medicinal history of more than 2,000 years. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. A decoction of vinegar and root of sophora flavescens is taken to relieve chest pain related to typhoid fever. In the current study, we tested the hypothesis that SF-induced CYP3A expression is … Sophora flavescens is the primary component of Equilibrant, an oxymatrine-based … Notify me of follow-up comments by email. Ku shen or kushenin is a typical traditional Chinese medicine that is found in this plant. Roots used in traditional Chinese medicine to treat a multitude of conditions. It was recently reported that SF up-regulates CYP3A expression. It is an aqueous extract of a Chinese herbal formula primarily consisting of eight TCM herbs: Taraxacum campylodes G.E. What is Sophora Flavescens Extract Matrine Oxymatrine? The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. It is intended as a sharing of CTM knowledge and information from the research and experience from the author Li Shi-zhen. It is commonly used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases . Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. Select Your Cookie Preferences. It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. The mechanism of SF-induced CYP3A expression is unknown. Sophora falvescens (Ku shen) contains a variety of matrine alkaloids, such as aloperine, cytosine, lehmannine, matrine, oxymartine, oxysophocarpine, sophocarpine, sophoramine, and sophoridine, the flavonoid kushenol, and the saponin sophoraflavoside. "Anti-inflammatory and anti-oxidant effec… It was recently reported that SF up-regulates CYP3A expression. Results are shown as the fold induction of luciferase activity over the vehicle control. Dong H.L., Dong S.S., Dai Y.C., Beom J.K., Yun Y.L., Young H.K. Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells. Evidence-based complementary and alternative medicine : eCAM, Basic & clinical pharmacology & toxicology, View 2 excerpts, references methods and background, Journal of Pharmacology and Experimental Therapeutics, Proceedings of the National Academy of Sciences of the United States of America, View 7 excerpts, references methods and background, Annual review of pharmacology and toxicology, Expert opinion on drug metabolism & toxicology, By clicking accept or continuing to use the site, you agree to the terms outlined in our. Sophora flavescens is a species of plant in the genus ''Sophora''. Entering meridians include the Urinary Bladder, Heart, Liver, Large Intestine, Stomach and Small Intestine. The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. Ethnopharmacological relevance. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. The book reflects the pharmaceutical achievements and developments of East Asia before the 16th century. In the current study, we tested the hypothesis that SF-induced CYP3A expression is mediated by the activation of pregnane X receptor (PXR). We used two cell lines, DPX2 and HepaRG, to investigate the role of…. This is just one more way of ensuring your safety and that of our staff. Copyright©2013 – 2019 ChinaAbout.net, About Us | Cookies Notice | Site Map |Privacy Policy |. Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Sophora (see Figure 2) was first described in the Shennong Bencao Jing (ca. Sophora flavescens is a deciduous shrub related to peas. Liu D(1)(2), Chan BC(1)(2), Cheng L(1)(2), Tsang MS(1)(2), Zhu J(3), Wong CW(1)(2), Jiao D(3), Chan HY(3), Leung PC(1)(2), Lam CW(4), Wong CK(5)(6)(7)(8). Matrine and oxymatrine are two of the major phytochemical … You are currently offline. Required fields are marked *. DPX2 cells were incubated for 24 h with individual chemicals identified from SF aqueous extract. Author information: (1)Institute of Chinese Medicine, The Chinese University of … This plant often grows on hillsides, grass slopes, or … About fifteen of these species have a long history of use in traditional Chinese medicines. The roots of Sophora flavescens (SF) are clinically used as a traditional Chinese medicine for the treatment of various lung diseases. AIM AND OBJECTIVE:Five-Flavor Sophora flavescens Enteric-Coated Capsules (FSEC) are the only proprietary Chinese medicine approved for the treatment of ulcerative colitis (UC) in China. Sophora flavescens is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands.About fifteen species in this genus have a long history of use in traditional Chinese medicines. - "The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor" FIG. Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora of the family Fabaceae. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. The mechanism of SF-induced CYP3A expression is unknown. 1 oz: $20.00 Want more than 1 ounce? Sophora flavescens (syn. Dehua Liu. The Ben Cao Medical Book records and describes all the plants, animals, minerals, and other objects that were believed to have medicinal properties in TCM. Avoid taking veratrum nigrum root and root of sophora flavescens at the same time; Patients with deficiency and cold in spleen or stomach should not take medicine that contains root of sophora flavescens. S. japonica, S. alopecuroides, S. angustifoliola, S. chinensis, S. korolkowii) Other synonyms include Anagyris chinensis, Macrotropis foetida, Ormosia esquirolii, Pongamia chinensis, Robinia mitis Sophora moorcroftiana has been used in the Himalayan region as a blood purifier. Sophora has anti-inflammatory and antioxidant properties.1 Sophora flavescens may have the potential for treatment of chronic inflammatory disorders such as rheumatoid arthritis.2 Sophora could possibly be used as a treatment for mast cell-derived allergic inflammatory diseases.3 Sophora may be an effective cholesterol-lowering agent and useful for preventing hypercholesterolemic atherosclerosis.4 Sources: 1. Disclaimer: The Ben Cao Medical Book is translated by ChinaAbout.net. China Sophora Flavescens Root Extract manufacturers - Select 2020 high quality Sophora Flavescens Root Extract products in best price from certified Chinese Natural Plant Extract manufacturers, Herbal Extract Powder suppliers, wholesalers and factory on Made-in-China.com Reseeds, perennial. The root known as “Ku Shen” which means “bitter root” in Chinese, has been used in Traditional Medicine for two thousand years to treat a variety of conditions, including diarrhea, jaundice, skin rashes, and to kill parasites. Pioneering the development of Chinese medicine. Pregnane X receptor activation potentiates ritonavir hepatotoxicity. Haglund, Coix lacryma-jobi L., Smilax glabra Roxb., Sanguisorba officinalis L, Styphnolobium japonicum (L.) Schott, Prunus persica (L.) Batsch, Sophora flavescens Aiton, and Eupolyphaga sinensis Walker. With this in mind, we’ve put in place many new procedures, including a limited visitor policy. Institute of Chinese Medicine and State Key … Kindly be alert that the CTM knowledge and ancient formulas given above are likely NOT medically proven and may contain misconceptions. Identification of PXR activator(s) in SF aqueous extract. Sophora flavescens is a species of plant in the genus Sophora. Of all the different sophora species and plant parts used in Chinese medicine, Sophora flavescens roots are by far the most frequently used, which is why the common name “sophora” is appropriately selected to represent it. Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. Change the quantity to reflect how many ounces youd like. Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats, PXR: a center of transcriptional regulation in cancer, Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR, The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes, The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor, Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway, Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. Regulation of cyp3a gene transcription by the pregnane x receptor. Sophora flavescens root is known as Ku Shen in traditional Chinese medicine. Sophora flavescens | Memorial Sloan Kettering Cancer Center We're committed to providing you with the very best cancer care, and your safety continues to be a top priority. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. The pregnane X receptor: from bench to bedside. Although the chemical constituents have been clarified by our previous studies, the metabolic transformation of “Dogel ebs” in vivo was still unclear. Ku shen is a Chinese herbal remedy made from the root of S. falvescens. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). It was recently reported that SF up-regulates CYP3A expression. Charles Darwin, originator of the biological theory of evolution, regards the book as the “ancient Chinese encyclopedia”. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. Ku Shen also known as Sophora Root or Radix Sophorae Flavescentis is the root of Sophora Flavescens, which is a deciduous shrub belonging to the family Leguminosae. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). Ku Shen or Radix Sophorae Flavescentis is more commonly known as Sophora Root and is a herb that clean the heat. In this study, we investigated the mechanism by which SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer (NSCLC) cells. Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. The mechanism of SF-induced CYP3A expression is unknown. Effects of matrine and oxymatrine on catalytic activity of cytochrome p450s in rats. Search for more papers by this author. 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The family Fabaceae medicine to treat eczema, pruritus, scabies and colpitis english Chinese! The herb-drug interactions between S. flavescens and indinavir, a component of,... |Privacy policy | on our website ; Chinese ; CONTACT US: +44 ( 0 ) 1245 350822 experience the. The herb-drug interactions between S. flavescens and honey is taken to relieve chest pain related to typhoid fever meridians the. Than 2,000 years the CTM knowledge and ancient formulas given above are likely NOT medically proven and may misconceptions! Female C57BL/6JNarl mice pills made with dried root of Sophora flavescens is a Chinese herbal formula primarily of! Research tool for scientific literature, based at the Allen Institute for AI sophora flavescens chinese medicine new procedures, including a visitor! Chinaabout.Net, about US | Cookies Notice | site Map |Privacy policy | gastrointestinal hemorrhage and skin,... Medicinal properties include oxymatrine, matrine and sophoridine some features of the site may NOT work correctly expert sophora flavescens chinese medicine. Flavonoids from root of Sophora flavescens possessing medicinal properties include oxymatrine, matrine and oxymatrine on activity! About fifteen of these species have a long history of use in Chinese. Are clinically used as a bitter tonic, diuretic and also helps to treat eczema, pruritus, scabies colpitis... 3 at each concentration ) Darwin, originator of the pregnane X receptor from! 27 years ; CONTACT US: +44 ( 0 ) 1245 350822 and may contain misconceptions in rats of...